Rapidly fatal acanthamoeba encephalitis and treatment of cryoglobulinemia.(DISPATCHES)(Author abstract)

From: Emerging Infectious Diseases | Date: March 1, 2007| Author: | Copyright information

Infection with Acanthamoeba, a free-living ameba, is a rare cause of slowly progressive granulomatous amebic encephalitis (GAE) in immunocompromised patients. This form of encephalitis is almost universally progressive and fatal, typically within 2 months of symptom onset (1). We describe a patient with cryoglobulinemia refractory to standard therapy who died of GAE after receiving rituximab.

Rituximab is a monoclonal antibody directed against CD20, a surface antigen expressed in cells of B-lymphocyte lineage. It was developed for treatment of B-cell lymphomas. Recently, ...

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