Aldosterone-induced Sgk1 relieves Dot1a-Af9-mediated transcriptional repression of epithelial [Na.sup.+] channel [alpha].(Research article)

Journal of Clinical Investigation | March 1, 2007| | Copyright

Aldosterone plays a major role in the regulation of salt balance and the pathophysiology of cardiovascular and renal diseases. Many aldosterone-regulated genes--including that encoding the epithelial [Na.sup.+] channel (ENaC), a key arbiter of [Na.sup.+] transport in the kidney and other epithelia--have been identified, but the mechanisms by which the hormone modifies chromatin structure and thus transcription remain unknown. We previously described the basal repression of ENaC[alpha] by a complex containing the histone H3 Lys79 methyltransferase disruptor of telomeric ...

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