Nephrogenic fibrosing dermopathy associated with exposure to gadolinium-containing contrast agents--St. Louis, Missouri, 2002-2006. From: Morbidity and Mortality Weekly Report | Date: February 23, 2007| Author: | COPYRIGHT 2007 U.S. Government Printing Office. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information) Copyright information

Nephrogenic fibrosing dermopathy (NFD) causes thickening and hardening of the skin, often in the extremities, and occurs in patients with underlying renal disease. The skin lesions can progress rapidly, sometimes leading to joint immobility and the inability to walk (1). In May 2006, nephrologists at hospital A in St. Louis, Missouri, reported to CDC and the Missouri Department of Health and Senior Services (MoDHSS) a cluster of NFD among patients treated in their dialysis units. CDC and MoDHSS conducted an investigation to determine the number of affected patients and identify ...

<0.05. 
 
([section]) N = 75. 
 
([paragraph]) N = 67. 
 
TABLE 2. Odds ratios (ORs) for selected characteristics 
among nephrogenic fibrosing dermopathy case-patients 
and matched controls * from hospital A--St. Louis, 
Missouri, December 2002--August 2006 
 
                            No. of 
                             case-        No. of 
Characteristic              patients     controls 
 
Comorbidities 
  History of deep 
    venous thrombosis          19           57 
 
  Presence of 
    dependent edema            18           49 
 
  History of 
    hypothyroidism             19           57 
 
Medications received 
  Erythropoietin 
      (high dose 
      versus low dose) 
    High maximum dose 
      (>

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