Agranular [CD4.sup.+]/[CD56.sup.+] hematodermic neoplasm: a distinct entity described in the recent World Health Organization-European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas. Archives of Pathology & Laboratory Medicine | January 1, 2007| | COPYRIGHT 2007 College of American Pathologists. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information) Copyright

* Agranular [CD4.sup.+]/[CD56.sup.+] hematodermic neoplasm is a distinct form of lymphoma with aggressive behavior and marked predilection for cutaneous involvement. Because of CD56 positivity, natural killer cells were initially suggested as the cell of origin in this tumor. In the recent World Health Organization-European Organization for Research and Treatment of Cancer classification, the term blastic natural killer cell lymphoma has been replaced with [CD4.sup.+]/[CD56.sup.+] hematodermic neoplasm because of its derivation from a plasmacytoid dendritic cell precursor. ...

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