Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity.(Research) From: Environmental Health Perspectives | Date: May 1, 2006| Author: Slotkin, Theodore A.; Levin, Edward D.; Seidler, Frederic J. | COPYRIGHT 2006 National Institute of Environmental Health Sciences. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group.Copyright information

A comparative approach to the differences between systemic toxicity and developmental neurotoxicity of organophosphates is critical to determine the degree to which multiple mechanisms of toxicity carry across different members of this class of insecticides. We contrasted neuritic outgrowth and cholinergic synaptic development in neonatal rats given different organophosphates (chlorpyrifos, diazinon, parathion) at doses spanning the threshold for impaired growth and viability. Anima...

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