Calcium:magnesium ratio in local groundwater and incidence of acute myocardial infarction among males in rural Finland.(Research)

From: Environmental Health Perspectives | Date: May 1, 2006| Author: | Copyright information

Several epidemiologic studies have shown an association between calcium and magnesium and coronary heart disease mortality and morbidity. In this small-area study, we examined the relationship between acute myocardial infarction (AMI) risk and content of Ca, Mg, and chromium in local groundwater in Finnish rural areas using Bayesian modeling and geospatial data aggregated into 10 km x 10 km grid cells. Data on 14,495 men 35-74 years of age with their first AMI in the years 1983, 1988, or 1993 were pooled. Geochemical data consisted of 4,300 measurements of each element in local ...

<2.28 mg/L) of well water Mg content compared with the risk with higher Mg levels (Table 2). In the highest tertile of Ca:Mg ratio (Ca:Mg ratio>

<2.28                35-39             36       38,745 
(n = 938) (b)        40-44             73       35,491 
                     45-49            128       33,212 
                     50-54            219       31,916 
                     55-59            293       33,104 
                     60-64            380       32,767 
                     65-69            369       29,614 
                     70-74            373       25,463 
                Age standardized    1,871      260,312 
2.28-3.12            35-39             70      105,405 
(n = 937) (b)        40-44            174       95,994 
                     45-49            310       85,030 
                     50-54            460       76,800 
                     55-59            677       79,417 
                     60-64            747       80,813 
                     65-69            845       75,137 
                     70-74            898       66,501 
                Age standardized    4,181      665,097><2.28                   93                64-124 
(n = 938) (b)          206               159-253 
                       385               320-453 
                       686               596-778 
                       885               785-987 
                     1,160             1,044-1,277 
                     1,246             1,120-1,374 
                     1,465             1,317-1,615 
                       622 (c)           591-649 
2.28-3.12               66                51-82 
(n = 937) (b)          181               155-208 
                       365               324-406 
                       599               545-654 
                       852               789-917 
                       924               859-991 
                     1,125             1,049-1,201 
                     1,350             1,263-1,439 
                       551 (c)           534-568>

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