Inner conflict: the fight to regulate the immune system in MS.

Inside MS | August 1, 2006| | Copyright

The FDA approval of Tysabri in 2004 and its withdrawal from the market three months later almost seemed like a cruel joke. As Ed Duggan, Maryland Chapter Board of Directors member, saw it: "Tysabri was the result of a rational, focused exploitation of a key new insight about the disease process in MS." There was a sense that researchers were gaining the upper hand.

And then, in early 2005, three people who had been given Tysabri developed PML, a rare but lethal disease seen in people whose immune systems have been suppressed. The promise of Tysabri's benefits was ...

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