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Intramuscular ophthalmic homatropine vs. atropine to prevent lethality in rates with dichlorvos poisoning.(Toxicology Observations)
Journal of Medical Toxicology
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December 1, 2006|
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COPYRIGHT 2006 University of Pennsylvania Press. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group.
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ABSTRACT
Introduction: Most hospitals lack a sufficient supply of atropine to treat, simultaneously, patients poisoned with multiple organophosphorous compound (OC) or nerve agent. The presence of a ubiquitous alternate antidote would prove useful if mass poisoning occurred. Our objective was to evaluate the effect of ophthalmic homatropine (Isopto Homatropine 5%) on survivability in a rat model of significant, acute OC poisoning.
Methods: Sprague-Dawley rats were randomized to one of five pre-treatment groups (N = 10 per group). Prior to experimentation, ...
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