On the question of sporadic or atypical bovine spongiform encephalopathy and Creutzfeldt-Jakob disease.(PERSPECTIVE) From: Emerging Infectious Diseases | Date: December 1, 2006| Author: Brown, Paul; Detwiler, Linda; McShane, Lisa M.; Zanusso, Gianluigi | COPYRIGHT 2006 U.S. National Center for Infectious Diseases. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group.Copyright information

Strategies to investigate the possible existence of sporadic bovine spongiform encephalopathy (BSE) require systematic testing programs to identify cases in countries considered to have little or no risk for orally acquired disease or to detect a stable occurrence of atypical cases in countries in which orally acquired disease is disappearing. To achieve 95% statistical confidence that the prevalence of sporadic BSE is no greater than 1 per million (i.e., the annual incidence of spo...

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