Catalytic antibodies: the generation of novel biocatalysts.

Chemistry and Industry | May 2, 1994| | Copyright

The world of science and medicine could be altered dramatically by the use of antibodies as catalysts in chemical reactions and drug therapy

One of the most cogent theories of how enzymes work is that they lower the free energy of the transition state for a reaction relative to the energy of the ground states for the reactants and products.|1,2~ This concept, originating from Haldane and Pauling, was used by Bill Jencks to describe the potential capacity of antibodies to act as enzymes. In his book on catalysis in chemistry and enzymology, he suggested that it might be ...

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