Early cellular responses of purine nucleoside-mediated protection of hypoxia-induced injuries of neuronal PC12 cells.

American Journal of Biochemistry and Biotechnology | June 22, 2005| | Copyright

Abstract: Hypoxia in brain may lead to cell death by apoptosis and necrosis. In parallel adenosine, a powerful endogenous neuroprotectant is formed. We wanted to investigate the effect of adenosine and its purine nucleoside relatives, inosine and guanosine on early cellular responses to hypoxia. [O.sub.2]-sensitive neuronal PC12-cells were subjected to chemical hypoxia induced with rotenone, an inhibitor of mitochondrial complex I. Loss of viability after hypoxic insult was impressively rescued by adenosine, guanosine and inosine. PC12-cells mainly express the A2A adenosine ...

Read all of this article with a FREE trial to HighBeam Research

Related newspaper, magazine, and trade journal articles from HighBeam Research

(Including press releases, facts, information, and biographies)

	The Enlightened Joseph Priestley: A Study of His Life and Work from 1773 to 1804.(Book review) Magazine article from: Church History ; The Enlightened Joseph Priestley: A Study of His Life and Work...Schofield's intellectual biography of Joseph Priestley (1733-1804). Forty years in...becomes the cornerstone. Reverend Joseph Priestley, amateur chemist, political liberal...
	The Enlightenment of Joseph Priestley: A Study of His Life and Work from 1733 to 1773.(Review) Magazine article from: Canadian Journal of History ; The Enlightenment of Joseph Priestley: A Study of His Life and Work...Schofield begins his biography of Joseph Priestley's early life with an account...was to be characteristic of Joseph Priestley's entire life" (p. 2...
	The death of Joseph Priestley: February 6th, 1804.(Months Past) Magazine article from: History Today ; ...Jefferson of the United rates wrote to Joseph Priestley, clergyman and chemist, when...sentiment. On the contrary, Priestley's radical views on religion...went on to Philadelphia, where Priestley was again received with flattering...
	Good management at Joseph Priestley College in Leeds, say inspectors. M2 Presswire ; ...Government: Good management at Joseph Priestley College in Leeds, say inspectors...Inspectorate of the inspection of Joseph Priestley FE College, located in Leeds...over. NOTES TO EDITORS 1. Joseph Priestley College inspection report is...
	A Founding Father Long Forgotten.(Periscope; PAGE TURNER)(Joseph Priestley) Magazine article from: Newsweek ; ...minister, scientist and polymath Joseph Priestley is credited with the discovery...founding principles. THE IDEA: Priestley deserves more than just a footnote...s more fantastical teachings, Priestley was given a hero's welcome in...
	The lightning & the key: a letter from William Franklin to Joseph Priestley.(Poem) Magazine article from: New Criterion ; ...perfectibility And never knew an end of inquiry, Who should say this one is not improved By death, who sought to profit by all means? Joseph, you recall when we were young, My father and I, how I followed him And how he doted on this "natural son" Made in his...
	Weekend: Archive - The rebel without a home; Jospeh Priestley was a mass of contradictions: a church Minister who denounced evolutionary theories, yet a scientist who discovered oxygen and photosynthesis. He came to work in Birmingham, but fled after a riot destroyed his home, says Chris Upton.(Features) Newspaper article from: The Birmingham Post (England) ; ...not have too long to wait. Joseph Priestley was something of a millennarian...Thomas Jefferson. We tend to see Joseph Priestley as a mass of contradictions...the word is 'rationality'. Joseph Priestley was born into the Age of Reason...
	Priestley was more than just a scientist.(Features) Newspaper article from: Birmingham Mail (England) ; ...both turbulence and talent, Joseph Priestley was both a controversial and...MEMORIAL... the statue of Joseph Priestley that stood in Victoria Square...Now CHAMBERLAIN SQUARE... Joseph Priestley statue is now by Birmingham...
	Renaissance genius, rebooted; Priestley would fit in digital world.(SHOW)(ON THE EDGE)(Column) Newspaper article from: The Washington Times ; ...In exile from his native England, Joseph Priestley (1733-1804) - chemist, political...Johnson's engrossing new portrait of Priestley and the intellectual milieu in which he thrived. Priestley, in other words, would have fit right...
	Priestley was more than just a scientist Newspaper article from: Birmingham Mail ; ...of both turbulence and talent, Joseph Priestley was both a controversial and inspirational...Surrey. In the succeeding years, Priestley gained a reputation not only as...supporter of intellectual liberty, Priestley was a firm believer in the importance...