Intact pks 15/1 in non-W-Beijing Mycobacterium tuberculosis isolates. From: Emerging Infectious Diseases | Date: May 1, 2006| Author: | COPYRIGHT 2006 U.S. National Center for Infectious Diseases. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group.Copyright information

To determine whether intact pks 15/1 is unique to the W-Beijing family, we investigated 147 Mycobacterium tuberculosis strains with different IS6110 genotypes. Intact pks 15/1 was found in 87.8% of cerebrospinal fluid and 84.9% of sputum isolates. It was found not only in W-Beijing strains ([approximately equal to] 97%) but also in other genotypes (38.5%-100%).

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Two structurally related families of cell envelope lipids, phthiocerol diesters and phenolic glycolipids, are virulence factors of Mycobacterium tuberculosis and M. leprae. They are also produced by ...