Of mice and molecules: research with genetically modified mouse models.(Essay on: Genetically Modified Mouse Models)

From: Environmental Health Perspectives | Date: August 15, 2005| Author: Shostak, Sara | Copyright information

During the first century of the development of the mouse as a model organism for biological research, mouse models were inbred with the goal of achieving genetic homogeneity within strains (Lowy and Gaudilliere 1998) and standardization at the locus of the gene (Rader 2004). Beginning in 1910, these mouse models "crossed the threshold of laboratories to replace human bodies," where they were investigated not as mice but as "living instruments" for the study of the human diseases (L...

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