The position not the presence of the halogen in corticosteroids influences potency and side effects. Journal of Drugs in Dermatology | February 1, 2006| | COPYRIGHT 2006 Journal of Drugs in Dermatology, Inc. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information) Copyright

Abstract

Many topical corticosteroids currently on the market contain a halogen substitution at the [C.sub.6], [C.sub.9], or the side-chain [C.sub.21] position of the corticosteroid skeleton. These modifications have enhanced the efficacy of corticosteroids as compared to hydrocortisone as topical anti-inflammatory agents, but have often increased side effects such as skin atrophy, adrenal suppression, and telangiectasia. These side effects have been attributed to the presence of halogens in the corticosteroid molecule and have raised concerns regarding the safety ...

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