Febuxostat found safe in renal-impaired patients: results show that at a dose of 80 mg/day, serum urate levels fell below 6 mg/dL in 48% of patients.(Musculoskeletal Disorders) From: Family Practice News | Date: January 15, 2006| Author: | COPYRIGHT 2006 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information) Copyright information

SAN DIEGO -- Febuxostat was more effective than allopurinol for management of gout, even in patients with moderate renal impairment, according to data from a company-sponsored trial.

The 28-week trial, Febuxostat vs. Allopurinol and Placebo in Subjects With Hyperuricemia and Gout, known as APEX, revealed that 4 of 9 gout patients with moderate renal impairment (serum creatinine between 1.6 and 2 mg/dL) who received febuxostat at a dose of 80 mg/day achieved a serum urate level less than 6 mg/dL in their Final three measurements, as did 5 of 11 patients who received 120 mg/day ...

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