Obesity, smoking, and aging.(CLINICAL CAPSULES)(Brief Article)

From: Internal Medicine News | Date: October 1, 2005| Author: | Copyright information

Obesity and cigarette smoking are associated with accelerated aging in white women, reported A.M. Valdes, Ph.D., of the Twin Research and Genetic Epidemiology Unit, St. Thomas' Hospital, London.

Both smoking and obesity result in oxidative stress, which increases white blood cell telomere erosion; telomeres protect chromosomes from degradation by capping the ends of the chromosomes. This suggests that obese subjects and smokers will have shortened telomeres, a marker for aging (Lancet 2005;366:662-4).

In a study of 1,122 white female twins aged 18-72 years, telomere ...

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