Genetic testing for celiac disease. From: Medical Laboratory Observer | Date: January 1, 2006| Author: | COPYRIGHT 2006 Nelson Publishing. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group.Copyright information

Celiac disease (CD) is a remarkably common immune-mediated disorder determined by both genetic risk [certain human leukocyte antigen (HLA) alleles] and one of the best characterized environmental triggers (gliadin) for any common autoimmune disease. The discovery of transglutaminase autoantibodies in celiac disease has allowed the identification of a large number of both symptomatic and asymptomatic individuals as having intestinal biopsy-confirmed celiac disease. As we gain further understanding of the long-term outcome of asymptomatic celiac disease and the specific interaction ...

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