Screening for Lynch syndrome.(Brief Article)

From: Internal Medicine News | Date: June 15, 2005| Author: | Copyright information

Molecular screening combined with immunohistochemical analysis can detect the Lynch syndrome, or hereditary nonpolyposis colorectal cancer, in patients with colorectal adenocarcinoma with greater accuracy than other criteria, reported Heather Hampel of Ohio State University, Columbus, and her colleagues.

In a group of 1,066 patients with colorectal adenocarcinoma, abnormalities of microsatellite instability were detected by immunohistochemical analysis in 123 of 132 tumors that had shown high-frequency microsatellite instability on genotyping. Only 10 of 70 tumors that had ...

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