A proposed mechanism to explain the stimulatory effect of melatonin on antioxidative enzymes.(Abstracts)(Brief Article) From: Alternative Medicine Review | Date: December 1, 2005| Author: Coto-Montes, A.; Tomas-Zapico, C. | COPYRIGHT 2005 Thorne Research Inc. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group.Copyright information

Melatonin, the main secretory product of the pineal gland, is known to collaborate against oxidative stress within cells, but its mechanism of action in terms of stimulating antioxidant enzymes remains unclear. Herein, we propose that melatonin modulates antioxidant enzyme activities via its interaction with calmodulin, which in turn inhibits downstream processes that lead to the inactivation of nuclear RORalpha melatonin receptor. Eventually,...

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