Associations of uric acid with polymorphisms in the [delta]-aminolevulinic acid dehydratase, vitamin D receptor, and nitric oxide synthase genes in Korean lead workers.(Research)

From: Environmental Health Perspectives | Date: November 1, 2005| Author: Ahn, Kyu-Dong; Jaar, Bernard G.; Kelsey, Karl T.; Lee, Byung-Kook; Lee, Sung-Soo; Lustberg, Mark E.; Parsons, Patrick J.; Schwartz, Brian S.; Silbergeld, Ellen K.; Todd, Andrew C.; Weaver, Virginia M.; Wen, Jiayu | Copyright information

Recent research suggests that uric acid may be nephrotoxic at lower levels than previously recognized and that it may be one mechanism for lead-related nephrotoxicity. Therefore, in understanding mechanisms for lead-related nephrotoxicity, it would be of value to determine whether genetic polymorphisms that are associated with renal outcomes in lead workers and/or modify associations between lead dose and renal function are also associated with uric acid and/or modify associations b...

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