Possible influence of [delta]-aminolevulinic acid dehydratase polymorphism and susceptibility to renal toxicity of lead: a study of a Vietnamese population.(Research)

From: Environmental Health Perspectives | Date: October 1, 2005| Author: Chia, Kee Seng; Chia, Sin Eng; Dong, Nguyen-Viet; Tham, Mei Theng; Tu, NguyenThi Hong; Yap, Eric; Zhou, Huijun | Copyright information

We examined six newly identified polymorphisms in the [delta]-aminolevulinic acid dehydratase (ALAD) single-nucleotide polymorphisms (SNPs) to determine if these SNPs could modify the relationship between blood lead (PbB) and some renal parameters. This is a cross-sectional study of 276 lead-exposed workers in Vietnam. All workers were measured for PbB, urinary retinol-binding protein (URBP), urinary [c.sub.1]-microglobulin (U[alpha]1m), urinary [[beta].sub.2]-microglobulin (U[beta...

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