Lung cancer risk after exposure to polycyclic aromatic hydrocarbons: a review and meta-analysis. From: Environmental Health Perspectives | Date: June 15, 2004| Author: | COPYRIGHT 2004 National Institute of Environmental Health Sciences. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group.Copyright information

Typical polycyclic aromatic hydrocarbon mixtures are established lung carcinogens, but the quantitative exposure-response relationship is less dear. To clarify this relationship we conducted a review and meta-analysis of published reports of occupational epidemiologic studies. Thirty-nine cohorts were included. The average estimated unit relative risk (URR) at 100 [micro]g/[m.sup.3] years benzo[a]pyrene was 1.20 [95% confidence interval (CI), 1.11-1.29] and was not sensitive to particular studies or analytic methods. However, the URR varied by industry. The estimated means in coke ...

<1         19         1.18 (1.12-1.23) 
By industry 
  Coke ovens                             10         1.17 (1.12-1.22) 
  Gasworks                                4         1.15 (1.11-1.20) 
  Aluminum                                8         1.16 (1.05-1.28) 
  (above three combined)                 22         1.17 (1.12-1.22) 
  Carbon                                  4        4.30 (0.81-22.79) 
  Asphalt                                 3        17.50 (4.21-72.78) 
  Tar distillery                          3        12.28 (0.48-314.4) 
  Chimney sweep                           2        16.24 (1.64-160.7) 
  Power                                   3><1           p(het) = 0.19 
By industry                                  p = 0.002 
  Coke ovens 
  Gasworks 
  Aluminum 
  (above three combined)                   p(het)><0.001><0.001><0.001>

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