Intrinsic factor antibody assay: access family of immunoassay systems.

From: Medical Laboratory Observer | Date: September 1, 2005 | Copyright information

Overview

Intrinsic factor (IF) is a single glycoprotein chain of 340 amino acids with carbohydrate residue and a molecular weight of about 44 kDa. Secreted by the parietal cells of the gastric mucosa, it plays an important role in the absorption of dietary vitamin B12 in the intestine.

Also known as cobalamin, vitamin B12 is necessary for the synthesis of red blood cells and maintenance of a healthy nervous system. Dietary vitamin B12 is released from ingested proteins in the stomach through the action of pepsin and acid. It is rapidly bound by one of two vitamin ...

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