Exposure to PCBs and p,p'-DDE and human sperm chromatin integrity.(Research)

From: Environmental Health Perspectives | Date: February 1, 2005| Author: | Copyright information

Persistent organochlorine pollutants (POPs) such as polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (p,p'-DDE), the major metabolite of dichlorodiphenyltrichloroethane (DDT), are stable lipophilic compounds widely found in the environment and in the general population. They can enter the food chain, and their negative impact on male reproduction is currently under active scrutiny. To explore the hypothesis that environmental exposure to these compounds is associated with altered sperm chromatin structure integrity in human sperm, we conducted a study of 176 ...

<0.001). This effect remained when age was included in the model (p = 0.006). The four highest exposed quintiles (><136 ng/g lipid) did not significantly differ from the four highest exposed quintiles (22%; 95% CI, -4 to 53; Figure 5). However, the exposure-response pattern for p,p'-DDE with respect to %DFI was similar as for CB-153 but not statistically significant. Neither CB-153 nor p,p'-DDE was associated with HDS (all p-values>

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