Bone as a possible target of chemical toxicity of natural uranium in drinking water.(Research)

From: Environmental Health Perspectives | Date: January 1, 2005| Author: | Copyright information

Uranium accumulates in bone, affects bone metabolism in laboratory animals, and when ingested in drinking water increases urinary excretion of calcium and phosphate, important components in the bone structure. However, little is known about bone effects of ingested natural uranium in humans. We studied 146 men and 142 women 26-83 years of age who for an average of 13 years had used drinking water originating from wells drilled in bedrock, in areas with naturally high uranium content. Biochemical indicators of bone formation were serum osteocalcin and aminoterminal propeptide of ...

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