Associations among lead dose biomarkers, uric acid, and renal function in Korean lead workers.(Research)

Environmental Health Perspectives | January 1, 2005| | Copyright

Recent research suggests that both uric acid and lead may be nephrotoxic at lower levels than previously recognized. We analyzed data from 803 current and former lead workers to determine whether lead biomarkers were associated with uric acid and whether previously reported associations between lead dose and renal outcomes were altered after adjustment for uric acid. Outcomes included uric acid, blood urea nitrogen, serum creatinine, measured and calculated creatinine clearances, and urinary N-acetyl-[beta]-D-glucosaminidase (NAG) and retinol-binding protein. Mean ([+ or -] ...

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