Two probable cases of serious drug interaction between clarithromycin and colchicine.(Case Report) From: Southern Medical Journal | Date: August 1, 2005| Author: Cheng, Vincent C.C.; Ho, P.L.; Yuen, K.Y. | COPYRIGHT 2005 Southern Medical Association. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group.Copyright information

Abstract: Although colchicine is a commonly used medication in patients with gouty arthritis and various multisystem disorders, its safety margin in therapeutic use is not well understood. This report describes two fatal cases of agranulocytosis presumed to result from a drug interaction involving colchicine and clarithromycin.

Key Words: colchicine, clarithromycin, drug-drug interactions

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Colchicine is a medication used in various medical...

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