The environmental estrogen bisphenol A inhibits estradiol-induced hippocampal synaptogenesis.(Research / Article) From: Environmental Health Perspectives | Date: June 1, 2005| Author: MacLusky, Neil J.; Hajszan, Tibor; Leranth, Csaba | COPYRIGHT 2005 National Institute of Environmental Health Sciences. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group.Copyright information

Bisphenol A (BPA) is an estrogenic chemical that is widely used in the manufacture of plastics and epoxy resins. Because BPA leaches out of plastic food and drink containers, as well as the BPA-containing plastics used in dental prostheses and sealants, considerable potential exists for human exposure in this compound. In this article we show that treatment of ovariectomized rats with BPA dose-dependently inhibits the estrogen-induced formation of dendritic spine synapses on pyramid...