Paternal occupational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and birth outcomes of offspring: birth weight, preterm delivery, and birth defects.(Children's Health / Article)

From: Environmental Health Perspectives | Date: October 1, 2004| Author: Connally, L. Barbara; Dankovic, David A.; Deddens, James A.; Lawson, Christina C.; Piacitelli, Laurie A.; Schnorr, Teresa M.; Sweeney, Marie H.; Whelan, Elizabeth A. | Copyright information

Agent Orange is a phenoxy herbicide that was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). We studied pregnancy outcomes among wives of male chemical workers who were highly exposed to chemicals contaminated with TCDD and among wives of nonexposed neighborhood referents. For exposed pregnancies, we estimated serum TCDD concentration at the time of conception using a pharmacokinetic model. The mean TCDD concentration for workers' births was 254 pg/g lipid (range, 3-1...

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