Effects of inhaled brevetoxins in allergic airways: toxin-allergen interactions and pharmacologic intervention.(Brevetoxins: Mini-Monograph) From: Environmental Health Perspectives | Date: May 1, 2005| Author: Abraham, William M.; Ahmed, Ashfaq; Baden, Daniel G.; Bourdelais, Andrea J.; Serebriakov, Irakli | COPYRIGHT 2005 National Institute of Environmental Health Sciences. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group.Copyright information

During a Florida red tide, brevetoxins produced by the dinoflagellate Karenia brevis become aerosolized and cause airway symptoms in humans, especially in those with pre-existing airway disease (e.g., asthma). To understand these toxin-induced airway effects, we used sheep with airway hypersensitivity to Ascaris suum antigen as a surrogate for asthmatic patients and studied changes in pulmonary airflow resistance ([R.sub.L]) after inhalation challenge with lysed cultures of K. brev...

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