Tazarotene cream versus adapalene cream in the treatment of facial acne vulgaris: a multicenter, double-blind, randomized, parallel-group study. Journal of Drugs in Dermatology | March 1, 2005| | COPYRIGHT 2005 Journal of Drugs in Dermatology, Inc. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information) Copyright

Abstract

A multicenter, double-blind, randomized, parallel-group trial compared tazarotene 0.1% cream with adapalene 0.1% cream, once daily for 12 weeks, in 173 patients with facial acne vulgaris. Tazarotene was associated with a significantly greater incidence of patients achieving 50% or greater global improvement (77% vs. 55%, P [less than or equal to] .01), and a significantly greater reduction in comedo count (median of 68% vs. 36%, P [less than or equal to] .001, compared with adapalene. A significant between-group difference in baseline inflammatory lesion ...

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