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Computerized image analysis of nails affected by fungal infection: evaluation using digital photographs and manually defined areas.(ARTICLES)
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Abstract
Despite the relevant increase in clinical trials on the efficacy of various systemic and/or topical antifungal agents in onychomycosis therapy, the evaluation of the results is largely subjective. The aim of this study was to set up and ensure an objective, reproducible and reliable method to measure nail plate involvement in onychomycosis. In order to validate a specifically designed software for the computerized image analysis of affected areas of the nail, standardized clinical pictures of onychomycosis were prepared by six different clinicians using a ...
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Electrocatalytic Oxidation of Guanine, Guanosine, and Guanosine Monophosphate
Magazine article from: Biophysical Journal
; ...ABSTRACT The electrochemical behavior of guanine, guanosine, and guanosine monophosphate...hydrogen electrode were determined for guanine and guanosine/GMP under physiological...The first to oxidize the base of DNA is guanine, oxidized either directly or through...
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RADICALS DERIVED FROM GUANINE: STRUCTURES AND ENERGETICS
Magazine article from: Collection of Czechoslovak Chemical Communications
; ...affinities (EA) of five radicals derived from guanine by removing a hydrogen atom are predicted...density functional methods. The most stable guanine radical arises from the removal of the...EA^sub ad^) for the five possible guanine radicals are substantial, in the range...
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Formation pathways of a guanine-quadruplex DNA revealed by molecular dynamics and thermodynamic analysis of the substates
Magazine article from: Biophysical Journal
; ...guanine quadruplex structure. Guanine quadruplexes are stabilized...layers of Hoogsteen paired guanine residues (Fig. 1 A), and...sequences containing stretches of guanines under physiological conditions...resolution data exist now for many guanine quadruplex structures adopted...
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New dihydro OO'bis(salicylidene) 2,2' aminobenzothiazolyl borate complexes: kinetic and voltammetric studies of dimethyltin copper complex with guanine, adenine, and calf thymus DNA.
Magazine article from: Bioinorganic Chemistry and Applications
; ...The interaction of complex (5) with guanine, adenine, and calf thymus DNA was studied...hyperchromic effect" in the presence of guanine and calf thymus DNA. Indicative of strong...binds through [N.sub.7] position of guanine base, while the adenine shows binding...
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Separation of guanine and hypoxanthine with some ionic liquids in RP-HPLC.(reversed phase high performance liquid chromatography)
Magazine article from: American Journal of Applied Sciences
; Abstract: In this paper, guanine and hypoxanthine were separated with...methylsulfate ([OMIm][MS]) were used. Guanine and hypoxanthine couldn't be separated...the ionic liquid for separation of guanine and hypoxanthine as an eluent modifier...
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Molecular Dynamics Simulations of Guanine Quadruplex Loops: Advances and Force Field Limitations
Magazine article from: Biophysical Journal
; ...architecture. INTRODUCTION Guanine quadruplex (G-DNA) molecules...sequences are particularly guanine-rich and readily form quadruplexes...cyclically hydrogen-bonded guanines. Several consecutive quartets...channel interacting with the guanine carbonyl groups between the...
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A REGIOSELECTIVE SYNTHESIS OF ALKYL 2-(GUANIN-9-YL)ACETATES AS PNA BUILDING BLOCKS FROM 7-(4-NITROBENZYL)GUANINE DERIVATIVES
Magazine article from: Collection of Czechoslovak Chemical Communications
; Guanine derivatives substituted at N^sup 7^ with 4...the regioselective N^sup 9^-alkylation of guanine. Given the capricious removal of (substituted) benzyl groups from guanine derivatives and pent-4-enoylation of guaninium...
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Guanosine assays can estimate the plasma biomarker guanine deaminase.
Newspaper article from: Biotech Week
; ...assays can estimate the plasma biomarker guanine deaminase. According to a study from Wales, "plasma guanine deaminase (guanase; GD) is well established...plasma GD activity is routine since both guanine and 8-azaguanine, the substrates of...
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Guanine nucleotide exchange protein involved in dendritic formation.
Newspaper article from: Drug Week
; ...localization of the mRNA for EFA6A, a guanine nucleotide exchange protein for ARF6...in dendritic formation. "EFA6A is a guanine nucleotide exchange protein (GEP) that...localization of the mRNA for EFA6A, a guanine nucleotide exchange protein for ARF6...
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Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor.
Newspaper article from: Obesity, Fitness & Wellness Week
; ...large protein, alsin, is a Rab5 and Rac1 guanine nucleotide exchange factor, and may play...that the Vps9p domain of alsin has Rab5 guanine nucleotide exchange activity. In addition...interacted specifically with and acted as a guanine nucleotide exchange factor for Rac1...
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