Subchronic exposure to TCDD, PeCDF, PCB126, and PCB153: effect on hepatic gene expression.(Toxicogenomics)

From: Environmental Health Perspectives | Date: November 15, 2004| Author: Olson, James R.; Vezina, Chad M.; Walker, Nigel J. | Copyright information

We employed DNA microarray to identify unique hepatic gene expression patterns associated with subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other halogenated aromatic hydrocarbons (HAHs). Female Harlan Sprague-Dawley rats were exposed for 13 weeks to toxicologically equivalent doses of four different HAHs based on the toxic equivalency factor of each chemical: TCDD (100 ng/kg/day), 2,3,4,7,8-pentachlorodibenzofuran (PeCDF; 200 ng/kg/day), 3,3',4,4',5-pentac...

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