The TAO-Gen algorithm for identifying gene interaction networks with application to SOS repair in E. coli.(Toxicogenomics)

From: Environmental Health Perspectives | Date: November 15, 2004| Author: Parham, Frederick M.; Portier, Christopher J.; Sone, Hideko; Toyoshiba, Hiroyoshi; Yamanaka, Takeharu | Copyright information

One major unresolved issue in the analysis of gene expression data is the identification and quantification of gene regulatory networks. Several methods have been proposed for identifying gene regulatory networks, but these methods predominantly focus on the use of multiple pairwise comparisons to identify the network structure. In this article, we describe a method for analyzing gene expression data to determine a regulatory structure consistent with an observed set of expression ...

Related newspaper, magazine, and journal articles from HighBeam Research

Bayesian models for gene expression with DNA microarray data.(Statistical Data Included)
Journal of the American Statistical Association ; ... various types of clustering algorithms, such as self-organizing maps, k-means clustering, and hierarchical clustering, to discriminate ... Interpreting Patterns of Gene Expression with Self-Organizing Maps: Methods and Application to Hematopoietic Differentiation, Proceedings ...
Empirical bayes analysis of a microarray experiment.(gene expression comparison)(Statistical Data Included)
Journal of the American Statistical Association ; ... Received 8 November, REFERENCES Alizadeh, A., Eisen, M., Davis, R. E., Ma, C., Lossos, I., Rosenwal, A., Boidrick, J., Sabet, H., Tran, T., Yu, X. J. P., Marti, G., Moore, T., Hudsom, J., Lu, L., Lewis, D., Tibshirani, R., Sherlock, G., Chan, W., Greiner, T ...
Light induction of cell type differentiation and cell-type-specific gene expression in cotyledons of a C4 plant, Flaveria trinervia
Plant Physiology ; Light Induction of Cell Type Differentiation and Cell-TypeSpecific Gene Expression in Cotyledons of a C^sub 4^ Plant, Flaveria trinervia1 In Flaveria trinervia (Asteraceae) seedlings, light-induced signals are required for differentiation of cotyledon bundle sheath cells and mesophyll cells and for
Genome-Wide Analysis of Hydrogen Peroxide-Regulated Gene Expression in Arabidopsis Reveals a High Light-Induced Transcriptional Cluster Involved in Anthocyanin Biosynthesis1[w]
Plant Physiology ; ... Maruyama K, Seki M, Hiratsu K, Ohme-Takagi M, Tran L-SP, Yamaguchi-Shinozaki K, Shinozaki ... Reactive oxygen signalling: the latest news. Curr Opin Plant Biol 7: 323-328 Larkindale ... Cell Res 15: 438-452 Ye Z, Rodriguez R, Tran A, Hoang H, de los Santos D, Brown S, Vellanoweth ...
Tracking Operator State Fluctuations in Gene Expression in Single Cells
Biophysical Journal ; ABSTRACT We report the results of operator state fluctuations in gene expression for the entire bacterial growth cycle, using single-cell analysis and synthetic unregulated and negative-feedback transcription regulatory gene circuits. In the unregulated circuit, during the cell cycle, we observe a
A Novel WRKY Transcription Factor Is Required for Induction of PR-1a Gene Expression by Salicylic Acid and Bacterial Elicitors[C][W]
Plant Physiology ; PR-1a is a salicylic acid-inducible defense gene of tobacco (Nicotiana tabacum). One-hybrid screens identified a novel tobacco WRKY transcription factor (NtWRKY12) with specific binding sites in the PR-1a promoter at positions -564 (box WK^sub 1^) and -859 (box WK^sub 2 NtWRKY12 belongs to the
Exogenous and endogenous transforming growth factors-beta influence elastin gene expression in cultured lung fibroblasts
American Journal of Respiratory Cell and Molecular Biology ; Elastin, an important structural protein of the extracellular matrix, confers elastic properties on the pulmonary alveolar interstitium. In the alveolar wall, elastin is primarily produced postnatally by fibroblasts. The mechanisms that regulate lung fibroblast (LF) elastin gene expression have not
cis-Regulatory Elements for Mesophyll-Specific Gene Expression in the C^sub 4^ Plant Flaveria trinervia, the Promoter of the C^sub 4^ Phosphoenolpyruvate Carboxylase Gene(W)
Plant Cell ; C^sub 4^ photosynthesis depends on the strict compartmentalization of CO2 assimilatory enzymes, cis-regulatory mechanisms are described that ensure mesophyll-specific expression of the gene encoding the C^sub 4^ isoform of phosphoenolpyruvate carboxylase (ppcA1) of the C^sub 4^ dicot Flaveria
Gene Expression Profiling in Patients with Chronic Obstructive Pulmonary Disease and Lung Cancer
American Journal of Respiratory and Critical Care Medicine ; Rationale: Chronic obstructive lung disease (COPD) is a commonand disabling lung disease for which there are few therapeutic options. Objectives: We reasoned that gene expression profiling of COPD lungs could reveal previously unidentified disease pathways. Methods: Forty-eight human lung samples
Interaction of NIMIN1 with NPR1 Modulates PR Gene Expression in Arabidopsis
Plant Cell ; The Arabidopsis thaliana NONEXPRESSER OF PR GENES1 (NPR1, also known as NIM1) protein is an essential positive regulator of salicylic acid (SA)-induced PATHOGENESIS-RELATED (PR) gene expression and systemic acquired resistance (SAR). PR gene activity is regulated at the level of redox-dependent