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Na[subscript]v1.5 can be ubiquitinated in heart tissues.
Life Science Weekly
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October 12, 2004
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2004 OCT 12 - (NewsRx.com & NewsRx.net) -- Cardiac voltage-gated sodium channel Na[subscript]V1.5 is regulated by Nedd4-2 mediated ubiquitination.
Scientists in Switzerland report, "Na[subscript]v1.5, the cardiac isoform of the voltage-gated Na[superscript]+ channel, is critical to heart excitability and conduction. However, the mechanisms regulating its expression at the cell membrane are poorly understood. The Na[subscript]v1.5 C-terminus contains a PY-motif (xPPxY) that is known to act as binding site for Nedd4/Nedd4-like ubiquitin-protein ligases. Because ...
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