Twenty-five patients with panic disorder with or without agoraphobia were randomly assigned to receive, in double-blind fashion, 6 g of inositol twice a day or placebo (mannitol or glucose) for four weeks, and then the alternate treatment for an additional four weeks. Twenty-one patients (mean age, 35.8 years) completed the trial. The frequency and severity of panic attacks and the severity of agoraphobia declined significantly more with inositol than with placebo. The number of attacks per week fell from about 10 to about 6 with placebo and to about 3.5 with inositol. Two ...

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