Mutant cytosine deaminase is an effective prodrug converter.

Gene Therapy Weekly | September 23, 2004 | Copyright

2004 SEP 23 - (NewsRx.com & NewsRx.net) -- Mutant cytosine deaminase is an effective prodrug converter.

"Suicide gene therapy of cancer is a method whereby cancerous tumors can be selectively eradicated while sparing damage to normal tissue. This is accomplished by delivering a gene, encoding an enzyme capable of specifically converting a nontoxic prodrug into a cytotoxin, to cancer cells followed by prodrug administration. The Escherichia coli gene, codA, encodes cytosine deaminase and is introduced into cancer cells followed by administration of the prodrug ...

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