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Does vitamin E cause heart failure?(Literature Review & Commentary)
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In the Heart Outcomes Prevention Evaluation (HOPE) study, 9,541 patients with cardiovascular disease or diabetes, plus one other cardiovascular risk factor, were randomly assigned to receive, in double-blind fashion, 400 IU/day of vitamin E (RRR-alpha-tocopheryl acetate) or placebo, and either an angiotensin-converting-enzyme inhibitor (ramipril) or placebo, for a mean of 4.5 years. Results of the study showed that ramipril was beneficial, but vitamin E was not.
At the end of the study, 6,786 patients agreed to enter a continuation phase, in which all patients ...
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