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The environmental origins of TSEs: the ferrimagneto-prion theory.(transmissible spongiform encephalopathy)(usage of ferrimagnetic substances for the treatment of mad cow fever)
From:
Townsend Letter for Doctors and Patients
| Date:
July 1, 2004| Author:
Purdey, Mark
| COPYRIGHT 2004 The Townsend Letter Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group.Copyright information
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The White Sands Missile Range is an extensive spread of US military controlled cacti country that spans the southernmost extremes of the San Andres mountain ridge. There is an eerie atmosphere to the place.
A Department of Natural Resources truck kicks up the dust across the dried out canyon, its engines reverberating in the quiet air. It stops at the main entrance gates along the perimeter fence. One of the wildlife officers gets out and walks to security, seemingly obli...
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The environmental origins of TSEs: the ferrimagneto-prion theory.(transmissible spongiform encephalopathy)(usage of ferrimagnetic substances for the treatment of mad cow fever)
Townsend Letter for Doctors and Patients
; The White Sands Missile Range is an extensive spread of US military controlled cacti country that spans the southernmost extremes of the San Andres mountain ridge. There is an eerie atmosphere to the place. A Department of Natural Resources truck kicks up the dust across the dried out canyon, its
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Evidence that the 127-164 region of prion proteins has two equi-energetic conformations with (beta) or (alpha) features
Biophysical Journal
; ABSTRACT Prion proteins cause neurodegenerative illnesses in humans and animals. The diseases are associated with a topological change from a predominantly alpha (PrP^sup c^) to gamma-sheet (PrP^sup sc^) structure. Many studies have focused on the minimum sequence requirements and key events for
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Protein conformation and diagnostic tests: The prion protein
Clinical Chemistry
; ... continue to keep TSEs in the news headlines and a priority among ... always fatal. Inherited disease maps exclusively to mutations in the ... Schiermeier Q. Testing times for BSE [News]. Nature 2001;409: 658-9. 5 ... Mad cow disease comes to Japan [News]. Nature 2001; 413:240. 6. Prusiner ...
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Electron paramagnetic resonance evidence for binding of Cu(2+) to the C-terminal domain of the murine prion protein
Biophysical Journal
; ABSTRACT Transmissible spongiform encephalopathies in mammals are believed to be caused by scrapie form of prion protein (PrP^sup Sc an abnormal, oligomeric isoform of the monomeric cellular prion protein (PrP^sup C One of the proposed functions of PrP^sup C^ in vivo is a Cu(II) binding activity.
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Agenda 2002: More people at risk of vCJD - study.(Features)
The News Letter (Belfast, Northern Ireland)
; Byline: JULIE WHELDON SCIENTISTS estimate that 120 people per million could be at increased risk of the human form of BSE but have not yet developed symptoms. The research, published in the British Medical Journal, is the first estimate of the number of people who could have pre-clinical variant
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Scientists are paid to prove that BSE was never a threat
Evening Standard - London
; ... disease called scrapie, which is similar to BSE but which has never been linked with brain disease in people. Their research, news of which could lead to protests from scientists who think the money would be better spent examining the main prion theory, is ...
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Mad cow and other maladies: update on emerging infectious diseases.
Baylor University Medical Center Proceedings
; ... Available at http://www.fda.gov/bbs/topics/NEWS/2003/NEW00999.html; accessed July 14 ... Available at http://www.fda.gov/bbs/topics/NEWS/2004/NEW01061.html; accessed July 14 ... release]. Available at http://www.hhs.gov/news/press/2004pres/20040126.html; accessed ... Mortal Wkly Rep 2004;53:100-103. (21.) ...
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Computational studies on prion proteins: Effect of Ala(117)-->Val mutation
Biophysical Journal
; ABSTRACT Molecular dynamics calculations demonstrated the conformational change in the prion protein due to Ala^sup 117gt;Val mutation, which is related to Gerstmann-Straussler-Sheinker disease, one of the familial prion diseases. Three kinds of model structures of human and mouse prion proteins
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Folding and misfolding of the prion protein in the secretory pathway
Amyloid
; KEY WORDS: prion, scrapie, endoplasmic reticulum, misfolding, neurodegeneration ABBREVIATIONS: PrP= prion protein; PrP^sup C^ = cellular prion protein; PrP^sup Sc^ = scruple prion protein; Prnp = prion protein gene; CJD = Creutzfeldt-Jakob disease; BSE = bovine spongiform encephalopathy; ER =
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BSE: a post-industrial disease?
Chemistry and Industry
; Hypotheses about the origin and behaviour of BSE and vCJD are taken as fact, but these certainties may be unfounded. Are we hindering the search for understanding? Recent cases of 'mad cow' disease in Europe have got people worried again. They are discussing the horrors of the brain rot caused by
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