Trypsin IV is a novel agonist of protease-activated receptors 2 and 4.

Biotech Week | June 2, 2004 | Copyright

2004 JUN 2 - (NewsRx.com & NewsRx.net) -- Trypsin IV is a novel agonist of protease-activated receptors 2 and 4.

"Certain serine proteases signal to cells by cleaving protease-activated receptors (PARs) and thereby regulate hemostasis, inflammation, pain and healing. However, in many tissues the proteases that activate PARs are unknown.

"Although pancreatic trypsin may be a physiological agonist of PAR[subscript]2 and PAR[subscript]4 in the small intestine and pancreas, these receptors are expressed by cells not normally exposed pancreatic trypsin. We ...

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