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Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells.
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We tested 200 pesticides, including some of their isomers and metabolites, for agonism and antagonism to two human estrogen receptor (hER) subtypes, hER[alpha] and hER[beta], and a human androge receptor (hAR) by highly sensitive transactivation assays using Chinese hamster ovary cells. The test compounds were classified into nine groups: urganochlorines, diphenyl ethers, organophosphorus pesticides, pyrethroids, carbamates, acid amides, triazines, ureas, and others. These pesticides wet tested at concentrations
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It has been well documented that several chemicals ...
<[10.sup.-6] M. Among these active pesticides, the RI[C.sub.20] of two diphenyl ether-type herbicides, CNP and chlomethoxyfen, were 4.3 x [10.sup.-8] M and 6.8 x [10.sup.-8] M, respectively, which is distinctly more potent than known AR antagonists such as vinclozolin and p,p'-DDE (1.6 x [10.sup.-7] M and 6.5 x [10.sup.-7] M, respectively). In addition, weak antiandrogen effects with RI[C.sub.20]>
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