Interlaboratory evaluation of rat hepatic gene expression changes induced by methapyrilene.(Genomics and Risk Assessment: Mini-Monograph) From: Environmental Health Perspectives | Date: March 15, 2004| Author: Beekman, Johanna M.; Flint, Nick; Kalkuhl, Arno; Lawton, Michael; Morfitt, David; Staedtler, Frank; Suter, Laura; Ulrich, Roger G.; Waring, Jeffrey F. | COPYRIGHT 2004 National Institute of Environmental Health Sciences. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group.Copyright information

Several studies using microarrays have shown that changes in gene expression provide information about the mechanism of toxicity induced by xenobiotic agents. Nevertheless, the issue of whether gene expression profiles are reproducible across different laboratories remains to be determined. To address this question, several members of the Hepatotoxicity Working Group of the International Life Sciences Institute Health and Environmental Sciences Institute evaluated the liver gene ex...