Rationale for the use of topical corticosteroids in melasma.(Articles)

From: Journal of Drugs in Dermatology | Date: March 1, 2004| Author: | Copyright information

Abstract

Corticosteroids have been combined with other agents in the treatment of melasma for years. In early studies by Kligman and Willis, topical dexamethasone as monotherapy produced little depigmentation even after 3 months of therapy. A significant concern is that topical corticosteroids used alone in this setting, especially on the face, may result in epidermal atrophy, telangiectasia, rosacea-like erythemas, acne, and perioral dermatitis.

Topical corticosteroids, however, including low-potency fluocinolone acetonide, also exert an anti-metabolic effect, resulting ...

Read all of this article with a FREE trial to HighBeam Research

Related newspaper, magazine, and trade journal articles from HighBeam Research

(Including press releases, facts, information, and biographies)

Specific treatment tips offered for treating specific populations
; ...treated after the laser procedure, preferably using the Kligman formula (equal parts 4% hydroquinone, 0.1% tretinoin cream, and...at high risk for postlaser hyperpigmentation, I begin the Kligman formula before any hyperpigmentation, generally about 2 weeks after...
Immunopathogenesis of psoriasis
; ...Psoriasis has for long been considered a hyperproliferative skin disease with a markedly increased (5-6 times normal) rate of epidermal turnover. This, along with the invariable presence of neutrophils within the epidermis of psoriatic lesions, led to the thinking...
Estrogen's keratinocyte connection
; ...presented in vitro data at the Society for Investigative Dermatology that suggest a direct link of the hormone to in vivo epidermal turnover and wound healing. "Our results demonstrate that in vitro physiologic concentrations of estradiol enhance keratinocyte...
Why our skin needs moisture
; ...that the moisture retention element of the skin's barrier function gradually diminishes with age. There's also reduced epidermal turnover time as we age, causing more wear and tear. Since surface cells are then older and rougher, skin looks and feels dry...
Melasma Tx
; ...event-related study withdrawals (3 percent). "The results of the PIGMENT Trial support the definitive conclusion that this Kligman formula-like, triple-combination cream is a rapidly and predictably effective treatment for melasma. Since Dr. Kligman introduced...
Balneo-phototherapy: A new holistic approach to treating psoriasis
; ...arthritis, hypertension, heart disease, diabetes, and depression (Rapp, Feldman, Exum, Fleischer, & Reboussin, 1999). The epidermal turnover time for a psoriatic skin cell is reduced from 14 days to 2. The faulty keratinization of the skin cells appears clinically...
Uncovering the nonablative facts
; ...associate professor of dermatology, Johns Hopkins University, Baltimore. "We believe that the mechanisms are inreased epidermal turnover, resulting in a new stratum corneum," he said. A less certain "fact" is that peels also produce an increase in anchoring...
Retinoids: The best cosmeceutical on the market
; ...retinoids as a class of vitamin A derivatives that are essential to normal hair, skin and nails. Topical use speeds up the epidermal turnover rate from 30 to 35 days to five to six days. Retinoids also repair DNA in epidermal cells, stimulate new collage production...
Better delivery vectors bring gene therapy closer to practical use
; ...Alto VA Medical Center. In a typical skin graft, gene expression may be entirely lost in 4 weeks over the course of one epidermal turnover cycle. But with the new, modified gene vector, gene transfer lasts through two, three, or more cycles, he said. The research...
The role of apoptosis in human epidermal keratinocytes.
; ...apoptosis, including the TNF alpha and Fas-mediated pathways are highlighted, with regards to utilization in normal human epidermal turnover. A firm understanding of the mechanisms of apoptosis in normal human epidermis may allow dermatologists to further appreciate...