Friedreich's ataxia: disease mechanisms, antioxidant and coenzyme Q10 therapy.(Abstracts)

From: Alternative Medicine Review | Date: March 1, 2004| Author: Cooper, J.M.; Schapira, A.H. | Copyright information

Cooper JM, Schapira AH, Biofactors 2003;18:163-171.

Mitochondria clearly play a central role in the pathogenesis of Friedreich's ataxia. The most common genetic abnormality results in the deficiency of the protein frataxin, which is targeted to the mitochondrion. Research since this discovery has indicated that mitochondrial respiratory chain dysfunction, mitochondrial iron accumulation and oxidative damage are important components of the disease mechanism. While the rol...

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