Concentrations of B vitamins and homocysteine in children with sickle cell anemia.(Original Article)

Southern Medical Journal | February 1, 2004| | Copyright

Background: Elevated concentration of serum homocysteine contributes to thrombosis, a frequent event in patients with sickle cell anemia. We aimed to test whether children with sickle cell anemia have elevated concentrations of serum homocysteine with diminished levels of folate or B vitamins from accelerated blood cell turnover.

Methods: We conducted a case-control study of children with homozygous sickle cell anemia (n = 17) and unaffected children (n = 11). We measured serum and red blood cell folate, vitamin [B.sub.6], vitamin [B.sub.12], and homocysteine ...

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