Voltage-dependent [Ca.sup.2+] fluxes in skeletal myotubes determined using a removal model analysis. The Journal of General Psychology | January 1, 2004| | COPYRIGHT 2004 Heldref Publications. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information) Copyright

INTRODUCTION

Contractile activation in muscle is initiated by a massive efflux of [Ca.sup.2+] ions from the SR. This [Ca.sup.2+] flux is tightly controlled by the plasma membrane voltage (Melzer et al., 1995; Dirksen, 2002; see Fig. 2 A). In experiments on isolated muscle cells, SR [Ca.sup.2+] release can be reproducibly triggered by plasma membrane depolarization. The precise synchronization with depolarization permits to study intracellular [Ca.sup.2+] release in muscle cells in better kinetic detail than in any other cellular system. The release flux of ...

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