Homing in on a key lung cancer gene. (protein-tyrosine phosphatase gamma gene)

From: Science News | Date: June 1, 1991| Author: | Copyright information

After years of sleuthing, scientists have identified a gene they believe is responsible for up to half of all cases of lung cancer.

Collaborators from eight U.S. institutions have turned up evidence that the gene's absence leads to large-cell lung carcinoma, one of the most common forms of cancer in both sexes. The gene directs the production of PTP-gamma, a member of a family of enzymes called protein-tyrosine phosphatases. These PTP enzymes act as receptors on the outer membranes of cells, receiving and translating incoming messages that tell the cell when to stop ...

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