Pharmacologic treatment of Alzheimer's disease: an update.(Clinical Pharmacology) From: American Family Physician | Date: October 1, 2003| Author: Delagarza, Vincent W. | COPYRIGHT 2003 American Academy of Family Physicians. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group.Copyright information

Alzheimer's disease is characterized by the development of senile plaques and neurofibrillary tangles, which are associated with neuronal destruction, particularly in cholinergic neurons. Drugs that inhibit the degradation of acetylcholine within synapses are the mainstay of therapy. Donepezil, rivastigmine, and galantamine are safe but have potentially troublesome cholinergic side effects, including nausea, anorexia, diarrhea, vomiting, and weight loss. These adverse reactions are often se...

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