Increased influence of genetic variation on PON1 activity in neonates.(Toxicogenomics) From: Environmental Health Perspectives | Date: August 15, 2003| Author: Berkowitz, Gertrud; Chan, Wendy; Chen, Jia; Kumar, Madhu; Wetmur, James G. | COPYRIGHT 2003 National Institute of Environmental Health Sciences. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group.Copyright information

PON1 (paraoxonase-1) detoxifies organophosphates by cleavage of active oxons before they have a chance to inhibit cholinesterases. The corresponding gene PON1 has common polymorphisms in both the promoter (-909, -162, -108) and the coding region (L55M, Q192R). The five PON1 genotypes were determined for maternal blood (n = 402) and cord blood (n = 229) as part of a study of the effects of organophosphate pesticide exposure on infant growth and neurodevelopment. PON1 enzymatic activ...