Intrinsic hepatic phenotype associated with the Cyp1a2 gene as shown by cDNA expression microarray analysis of the knockout mouse. (Article).

From: Environmental Health Perspectives | Date: May 15, 2003| Author: Dalton, Timothy P.; Davies, Reginald; Gant, Timothy; Judah, David; Miller, Marian L.; Nebert, Daniel W.; Riley, Joan; Smith, Andrew G. | Copyright information

Several forms of cytochrome P450 (CYP) appear to metabolize principally pharmaceutical agents, as well as other dietary and plant chemicals. Other CYP forms have major roles in steroid, sterol, and bile acid metabolism. CYP1A2 expression is constitutively high in mouse liver and is well known for metabolizing several drugs and many procarcinogens to reactive intermediates that can cause toxicity or cancel. CYP1A2 is also known to carry out several endogenous functions such as uropo...

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